What do the liver and ovaries have in common?

Interacting dysfunction in the setting of the standard Western diet. In the article below, we see how a high-fat diet causes insulin resistance, the metabolic disturbance behind many pathologies from type 2 diabetes to fatty liver disease to polycystic ovarian syndrome. Hyperinsulinemia from negative feedback actually decreases hepatic production of sex hormone binding globulin. Less binding-> more free testosterone and hyperandogenism. It also signals the pituitary to increase luteinizing hormone and decrease follicle-stimulating hormone, exacerbating hyper-T and causing anovulation. How amazing are these PhD’s elucidating the mechanisms for us. Let us repay them by applying the knowledge and counseling patients on the only definitive treatment for insulin resistance: whole, plant foods. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093689/#:~:text=Core%20tip%3A%20Nonalcoholic%20fatty%20liver,to%20the%20development%20of%20NAFLD.