The mischievous prostate

Evidence abounds not only for primary prevention but also secondary prevention of prostate cancer (pCA) via plant-based eating. First note that up to 40% of cancer in general is attributable to diet. Other hefty percentages come from smoking, alcohol, and human papilloma virus which leave only 5-10% from genetic etiologies alone. Helping patients understand this can be very empowering for them. Some points on the relation between diet and prostate:


-excess cholesterol is a substrate for androgen synthesis
-cooking meat creates heterocyclic amines which are closely associated with pCA
-so are bioconcentrated pollutants like the polychlorinated biphenyls (PCB’s) found in fatty fish
-dairy consumption increases insulin-like growth factor 1 (makes sense since cow’s milk functions to stimulate growth in calves), which is linked to pCA
-protective plant compounds (phytonutrients) for pCA include lycopenes in tomatoes, sulforaphanes in cruciferous greens like broccoli and in alliums like onions, and catechin in green tea


Phew. And remember that much of the same science applies to breast and gynecologic cancers.
https://academic.oup.com/jncics/article/3/2/pkz034/5492023
https://juniperpublishers.com/ctoij/CTOIJ.MS.ID.555813.php#atype
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691666/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754664/